[{"@context":"https:\/\/schema.org\/","@type":"Article","@id":"https:\/\/www.greka.cz\/jak-zpomalit-demenci\/#Article","mainEntityOfPage":"https:\/\/www.greka.cz\/jak-zpomalit-demenci\/","headline":"Jak zpomalit demenci","name":"Jak zpomalit demenci","description":"Kv\u016fli tomu, \u017ee populace st\u00e1rne, za\u010d\u00ednaj\u00ed se objevovat onemocn\u011bn\u00ed, kter\u00e9 nikdy d\u0159\u00edve nebyly tak b\u011b\u017en\u00e9. \u0158e\u010d je o demenc\u00edch, jejich\u017e prevalence a z\u00e1va\u017enost se u star\u0161\u00edch ro\u010dn\u00edk\u016f zvy\u0161uje. Jednou z\u00a0nejzn\u00e1m\u011bj\u0161\u00edch a nej\u010dast\u011bj\u0161\u00edch je Alzheimerova demence. Toto onemocn\u011bn\u00ed nen\u00ed je\u0161t\u011b \u00fapln\u011b p\u0159esn\u011b vysv\u011btleno a pops\u00e1no. Jako jeden z\u00a0mechanism\u016f se jev\u00ed vnik beta amyloidu. Jedn\u00e1 se o […]","datePublished":"2023-07-28","dateModified":"2024-03-28","author":{"@type":"Person","@id":"https:\/\/www.greka.cz\/author\/#Person","name":"","url":"https:\/\/www.greka.cz\/author\/","identifier":1,"image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/afe3e9c307ddf0b756c397ad75c6ecdba1f9da628b10651fe33a13bba6407ccd?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/afe3e9c307ddf0b756c397ad75c6ecdba1f9da628b10651fe33a13bba6407ccd?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"greka.cz","logo":{"@type":"ImageObject","@id":"\/logo.png","url":"\/logo.png","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/www.greka.cz\/wp-content\/uploads\/art489648_1x1_20261007_233508_6c5kgh.jpg","url":"https:\/\/www.greka.cz\/wp-content\/uploads\/art489648_1x1_20261007_233508_6c5kgh.jpg","height":0,"width":0},"url":"https:\/\/www.greka.cz\/jak-zpomalit-demenci\/","about":["Zdrav\u00ed"],"wordCount":377,"articleBody":"\tKv\u016fli tomu, \u017ee populace st\u00e1rne, za\u010d\u00ednaj\u00ed se objevovat onemocn\u011bn\u00ed, kter\u00e9 nikdy d\u0159\u00edve nebyly tak b\u011b\u017en\u00e9. \u0158e\u010d je o demenc\u00edch, jejich\u017e prevalence a z\u00e1va\u017enost se u star\u0161\u00edch ro\u010dn\u00edk\u016f zvy\u0161uje. Jednou z\u00a0nejzn\u00e1m\u011bj\u0161\u00edch a nej\u010dast\u011bj\u0161\u00edch je Alzheimerova demence. Toto onemocn\u011bn\u00ed nen\u00ed je\u0161t\u011b \u00fapln\u011b p\u0159esn\u011b vysv\u011btleno a pops\u00e1no. Jako jeden z\u00a0mechanism\u016f se jev\u00ed vnik beta amyloidu. Jedn\u00e1 se o metabolity protein\u016f, kter\u00e9 se v\u00a0CNS b\u011b\u017en\u011b nach\u00e1z\u00ed. U star\u0161\u00edch lid\u00ed se tyto proteiny rozkl\u00e1daj\u00ed za vzniku nezpracovateln\u00e9ho amyloid\u016f, kter\u00fd se doslova usazuje na specifick\u00fdch m\u00edstech mozku, a tak zp\u016fsobuje typick\u00e9 projevy. Velmi d\u016fle\u017eit\u00e9 je po\u010d\u00ednaj\u00edc\u00edho Alzheimera odhalit a za\u010d\u00edt i v\u00a0po\u010d\u00e1te\u010dn\u00edch f\u00e1z\u00edch l\u00e9\u010dit. \tSice je\u0161t\u011b st\u00e1le nejsme schopni tuto nemoc \u00fapln\u011b odstranit, jsme ale schopni jej\u00ed rozvoj velmi v\u00fdrazn\u011b odd\u00e1lit. Krom\u011b jin\u00e9ho je patrn\u00e9, \u017ee u lid\u00ed trp\u00edc\u00edch Alzheimerem je v\u00a0mozku sn\u00ed\u017een\u00e9 mno\u017estv\u00ed acetylcholinu, na co\u017e farmakologicky m\u00ed\u0159\u00edme. Inhibujeme toti\u017e enzym, kter\u00fd acetylcholin rozkl\u00e1d\u00e1. Tato l\u00e9\u010diva nesou n\u00e1zev donepezil, rivastigmin, galantamin. U z\u00e1va\u017en\u011bj\u0161\u00edch stav\u016f se pak vyu\u017e\u00edv\u00e1 memantin. Krom\u011b toho, pokud je ji\u017e v\u00a0mozku vytvo\u0159en amyloid a my jsme jej prok\u00e1zali pomoc\u00ed zobrazovac\u00edch metod, jsme schopni c\u00edlit i na n\u011bj. Jde to pomoc\u00ed monoklon\u00e1ln\u00edch protil\u00e1tek aducanumab, lecanemab nebo donamemab. \tSpeci\u00e1ln\u00ed skupinou l\u00e1tek jsou nootropika. T\u011bm se v\u00a0angli\u010dtin\u011b p\u0159ezd\u00edv\u00e1 tak\u00e9 smart drugs. Jedn\u00e1 se toti\u017e o l\u00e1tky, kter\u00e9 prokazateln\u011b zlep\u0161uj\u00ed stav mozku. Pou\u017e\u00edvaj\u00ed se tak po c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhod\u011b, u poruch v\u011bdom\u00ed nebo u p\u0159ed\u010dasn\u011b narozen\u00fdch d\u011bt\u00ed. Tyto l\u00e1tky zlep\u0161uj\u00ed pr\u016ftok krve mozkem, jeho zpracov\u00e1n\u00ed kysl\u00edku a gluk\u00f3zy a tak\u00e9 urychluj\u00ed odbour\u00e1v\u00e1n\u00ed lakt\u00e1tu. Farmakologie jako\u017eto v\u011bda o l\u00e9\u010divech je velmi zaj\u00edmav\u00e1 a sk\u00fdt\u00e1 mnoh\u00e1 p\u0159ekvapen\u00ed. St\u00e1le zde existuj\u00ed neprob\u00e1dan\u00e1 pole, kter\u00e1 mohou m\u00edt velk\u00fd potenci\u00e1l pro zlep\u0161en\u00ed lidsk\u00e9ho zdrav\u00ed.\t                                                                                                                                                                                                                                                                                                                                                                                                "},{"@context":"https:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Jak zpomalit demenci","item":"https:\/\/www.greka.cz\/jak-zpomalit-demenci\/#breadcrumbitem"}]}]